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Abstract
A novel series of Schiff bases, incorporating sulfonamide derivatives and 4-acyl-2-pyrazol-5-one, were synthesized using a simple condensation method. The structures of these newly synthesized compounds were comprehensively characterized through various techniques, including 1H NMR, FT-IR, ESI-MS, elemental analysis and 13C NMR spectroscopy. The structural properties of the studied molecules were investigated theoretically by carrying out Density Functional Theory (DFT). These newly synthesized compounds were then subjected to evaluation for their antibacterial activity against both gram +ve and gram -ve bacterial strains, as well as antioxidant assay. Additionally, they were screened for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37RV, with all results compared against a standard drug.