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Abstract
Epilepsy is one of the common central nervous system (CNS) related disorder of animals and human beings. There is a high need for the development of new and upgraded antiepileptic drugs (AED) to treat epilepsy. The purpose of the present research was to investigate the antiepileptic effect of ethanol extract of Datura stramonium leaf on animal models and to describe AED therapy patterns in a real-world setting. This experimental investigation also aims to evaluate the differences in outcomes by collaborating with Diazepam, a benzodiazepine used for the treatment of seizer and epilepsy and status epilepticus in epilepsy. The entire plant is a reservoir of nutritional phytonutrients and micronutrients. Pentylenetetrazole (PTZ) induced seizer models were used to screen for the antiseizure activity of Datura stramonium leaf extracts. The role of antiepileptic pharmaceuticals is to provide equilibrium between Gamma-aminobutyric acid (GABA), an inhibitory brain neurotransmitter, and glutamate, which functions as an excitatory neurotransmitter. Oxidative stress parameters like level of lipid peroxide, percentage inhibition of super oxide dismutase, activity of catalase, and level of reduced glutathione were executed with normal, PTZ-induced and treated animals. The histopathology of a region of brain tissue of treated animals showed there is increased neuronal density, which is comparable with diazepam. All the results were expressed as mean ± standard deviation. The findings of this study give evidence for the protective effect of Datura stramonium plant extract in controlling epilepsy. The phytonutrients in the studied plant significantly lowered PTZ-induced seizures and the results were compared with that of standard drug diazepam.