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Abstract
Abstract: Cancer disease often spreads and causes premature death. Chemotherapy using heterocyclic compounds, like indoles, promises to be an effective option for cancer treatment. Simple procedures were introduced to prepare seven 1H-indole-2-carboxamide derivatives. Characterization was performed using spectroscopic techniques such as infrared and nuclear magnetic resonance spectroscopy, and elemental analysis. The prepared compounds were evaluated biologically against human prostate cancer cell line (PC3), human, invasive breast ductal carcinoma (MCF-7), and breast cancer cell line-231 (MDA) alongside normal dermal fibroblasts. All compounds showed a moderate potency in PC3 having 23 to >50 µg/mL half maximal inhibitory concentration. The activity of the compounds was based on the presence of N-H in the indole system, amide, and phenyl groups at the specified positions. The synthesized compounds exhibited no inhibitory activity against the MDA cancer cell line.