Electrochemical Determination of Omeprazole at Molybdenum Disulfide Modified Glassy Carbon Electrodes

Abstract

Abstract: Molybdenum disulfide, MoS₂, is commonly used as a substrate in supercapacitors and other energy production systems, but it is of limited utility in pharmaceutical analysis. In this article, a molybdenum disulfide composite was prepared, and the electro-activity of MoS₂ toward the oxidation of omeprazole (OMZ) was investigated. The molybdenum disulfide content of the prepared material was quantified by thermal gravimetric analysis (TGA), its crystallinity revealed by X-ray diffraction (XRD, and its topographic features were probed by scanning electron microscopy (SEM). Glassy carbon electrode was modified by MoS₂, and the electrochemical activity of the modified electrode toward omeprazole oxidation was investigated in a phosphate buffer solution (pH 7.00) using differential pulse voltammetry (DPV). The well-resolved anodic peak at ca. 0.85 V vs Ag/AgCl was reported at the modified and bare glassy carbon electrodes. The impact of the modification with MoS₂ was noticed as a 2.3-fold enhancement of the OMZ oxidation current. Under the applied experimental conditions and utilising the modified electrode, a linear response was obtained in the range of 15.8–500. μM with a limit of detection equal to 4.74 μM and a correlation coefficient of 0.989. The modified electrode was also employed to detect omeprazole in its commercial pharmaceutical formulations. Percent recovery values of 84.0 to 100.% were reported.