Oxime-based Schiff base ligands draw current attention due to their indispensable analytical applications and amazing capacity to form a large variety of complexes of different nuclearities. They can connect metal ions through their nitrogen as well as deprotonated oxygen to synthesize multinuclear spin coupled magnetic molecules of significant importance. This versatile coordinating ability and simple tunability of their properties by adjusting the substituents make the ligand more attractive to the current research. Biological activities of some oxime metal complexes, especially Cu and Ni, give an additional dimension in this area. Keeping all these ideas in mind, many research groups are engaged in synthesizing different complexes of this special type of ligand over many decades. This article presents an overview of the synthetic strategies, structural elucidations of different Schiff base ligands involving biacetyl monoxime and a set of diamines and their Cu and Ni complexes during the last twenty years and it offers a platform to continue further work with these ligands. It is worthy to point out that only those complexes the X-ray crystal structures of which are available are considered in this review.