Cap H-point standard addition method for the simultaneous spectrophotometric determination of captopril and hydrochlorothiazide in pharmaceutical formulations
Vol. 16 No. 2 (2021), Articles
Vol. 16 No. 2 (2021)

Cap H-point standard addition method for the simultaneous spectrophotometric determination of captopril and hydrochlorothiazide in pharmaceutical formulations: Simultaneous spectrophotometric determination of captopril and hydrochlorothiazide

Articles
Lazeeza Sattar
College of pharmacy/Hawler Medical University
Dr.
Department of Chemistry, College of Education, Mosul University,Mosul, Iraq.
Asmaa Ghanim Dawood
Department of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Erbil, Iraq

Keywords

H-point standard addition method, Captopril, Hydrochlorothiazide.

How to Cite

Sattar, L., Habeeb, N. N. ., & Dawood , A. G. . (2022). Cap H-point standard addition method for the simultaneous spectrophotometric determination of captopril and hydrochlorothiazide in pharmaceutical formulations: Simultaneous spectrophotometric determination of captopril and hydrochlorothiazide. Jordan Journal of Chemistry (JJC), 16(2). Retrieved from https://jjc.yu.edu.jo/index.php/jjc/article/view/434
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Abstract

The H-point standard addition method was used for the simultaneous spectrophotometric determination of captopril and hydrochlorothiazide in pharmaceutical formulations, absorbances in wavelength pairs λ 211.5 and λ 230.3 nm, were monitored with the addition of standard captopril solutions. Captopril and hydrochlorothiazide concentration ratios are estimated to be 1.0:0.8 and 2.5:15,recovery at 95.33% - 104.37% and 96.8% - 105% respectively,  with a precision of up to 2.The method was successfully used to evaluate the antihypertensive captopril drug in a binary combination of hydrochlorothiazide in real samples with high precision and accuracy within the recovery percentage.