Six Coordinate Transition Metal (II) Complexes of Mixed Ligands of Eflornithine Hydrochloride Hydrate and 2,2-Bipyridine: Synthesis, Characterization and Antibacterial Study
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Keywords

Eflornithine hydrochloride hydrate, 2,2-Bipyridine, Carboxylate, Bidendate ligand, In-vitro anti-bacterial activities

How to Cite

Wahab A. Osunniran. Joshua A. Obaleye. Yusuf O. Ayipo. Abdullahi O. Rajee. Edith A. Enemose. (2018). Six Coordinate Transition Metal (II) Complexes of Mixed Ligands of Eflornithine Hydrochloride Hydrate and 2,2-Bipyridine: Synthesis, Characterization and Antibacterial Study. Jordan Journal of Chemistry (JJC), 13(3), 149-157. Retrieved from https://jjc.yu.edu.jo/index.php/jjc/article/view/39

Abstract

Transition M(II): Cu(II), Ni(II) or Co(II) metal complexes of mixed Eflornithine hydrochloride hydrate (EFN) and 2,2-bipyridine (bipy) ligands have been synthesized by 1:1:1 ratio of EFN:bipy:M(II). The metal complexes have been characterized using elemental analysis, FTIR, electronic spectra, melting point, magnetic susceptibility measurements and conductivity measurements. The physicochemical data obtained revealed [M(EFN)(bpy)X2]•(H2O)m•(HCl)n as a proposed molecular formula of the complexes, where M= Ni(II), Co(II) and Cu(II); X= Cl, H2O, m= 2 or 3 and n = 1 or 2. The results of conductivity measurement showed that the ligand (EFN) and metal complexes are sensitive to electric current in the solution. The FTIR spectral data suggests that EFN and bipy behave as bidentate ligands coordinating to the metal ions through an oxygen atom of the carboxylate and a nitrogen atom of amino group of EFN and through nitrogen atoms of bipy. Electronic spectral and magnetic studies data suggests octahedral geometry around metal ions. For the in-vitro anti-bacterial activities, the ligand and metal complexes were screened using agar diffusion method against two gram-positive bacteria and two gram-negative bacteria. Metal complexes showed higher antibacterial activities than the parent ligand and compete favorably well with the antibiotic used as control. The enhanced activities of metal complexes can be adduced to the presence of bipy ligand>

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