Solid Phase Synthesis and Antiparasitic Activity of a Library of Peptidyl Metronidazoles

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Keywords

Metronidazole; Peptides; Solid phase synthesis; Biological Activity.

How to Cite

Al-Gharabli, S. (2021). Solid Phase Synthesis and Antiparasitic Activity of a Library of Peptidyl Metronidazoles. Jordan Journal of Chemistry (JJC), 5(2), 139-147. Retrieved from https://jjc.yu.edu.jo/index.php/jjc/article/view/292 (Original work published April 19, 2010)

Abstract

A number of peptidyl metronidazole derivatives were synthesized in 99% yield through
solid phase peptide synthesis. The newly prepared compounds were tested against Entamoeba
histolyticaand Giardia intestinalisand were found to be much less active than metronidazole
against the aforementioned parasites; apparently the introduction of the peptide moiety on the
metronidazole nucleus has an adverse effect on their antiparasitic activities. Nevertheless,
grafting metronidazole with amino acids opens the window for parallel screening and
combinatorial approaches

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