Antibacterial Activity of Functionalized 1-(2',4'-Dihydroxy-5'-Substituted Phenyl)-3-Thienyl-Propane-1,3-Diones Bearing Potential O,O,S-Pharmacophores
Vol. 6 No. 1 (2011), Articles
Vol. 6 No. 1 (2011)

Antibacterial Activity of Functionalized 1-(2',4'-Dihydroxy-5'-Substituted Phenyl)-3-Thienyl-Propane-1,3-Diones Bearing Potential O,O,S-Pharmacophores

Articles
  • Javed Sheikh*, Harjeet Juneja, Parvez Ali, Vishwas Ingle
Javed Sheikh*, Harjeet Juneja, Parvez Ali, Vishwas Ingle

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Keywords

β-Diketones; Baker-Venkataraman rearrangement; Antibacterial activity; SAR.

How to Cite

Sheikh, J. (2021). Antibacterial Activity of Functionalized 1-(2’,4’-Dihydroxy-5’-Substituted Phenyl)-3-Thienyl-Propane-1,3-Diones Bearing Potential O,O,S-Pharmacophores. Jordan Journal of Chemistry (JJC), 6(1), 107-112. Retrieved from https://jjc.yu.edu.jo/index.php/jjc/article/view/271 (Original work published July 21, 2010)
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Abstract

A series of highly functionalized 1-(2',4'-dihydroxy-5'-substituted phenyl)-3-thienyl-propane-1,3-diones 3a-g have been produced upon Baker-Venkataraman rearrangement of 4-hydroxy-5-substituted-2-thienoyloxyacetophenones 2a-g using dimethylsulphoxide in NaOH. All the synthesized motifs 3a-g were confirmed by the spectroscopic analyses and evaluated for antibacterial efficacy against different pathogens.

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