Utilization of 2-Ylidene-4-Thiazolidinones in the Synthesis of Heterocyclic Compounds Part III: Synthesis and In-Vitro Antibacterial Activity Evaluation of Thienopyrimidinone Derivatives
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Keywords

3-amino-2-thiophenecarboxamides, dihydrothienopyrimidinones, tetrahydrothienopyrimidinones, antibacterial activity

How to Cite

Mahmoud F. Farhat*, Ahmed M. El-Saghier, Suhilla Kh. Elnami, Nisrin A. Dwaya, Asma O. Jebril, Asma O. Errayes, Moftah O. Darwish and Mohammed S. Ibrahim. (2019). Utilization of 2-Ylidene-4-Thiazolidinones in the Synthesis of Heterocyclic Compounds Part III: Synthesis and In-Vitro Antibacterial Activity Evaluation of Thienopyrimidinone Derivatives. Jordan Journal of Chemistry (JJC), 14(1), 39-47. Retrieved from https://jjc.yu.edu.jo/index.php/jjc/article/view/26

Abstract

3-Amino-2-thiophenecarboxamides (3a, d-g) were synthesized from 2-(4-oxo-3-phenyl- thiazolidin-2-ylidene)malononitrile (2) and employed in the synthesis of a variety of thiophene and thienopyrimidinone derivatives. 3-Amino-2-thiophenecarboxamides (3a, d, e) on refluxing in acetic acid gave the tetrahydrothienopyrimidinones (6a-m). On the other hand, the reaction of the 3-amino-2-thiophenecarboxamides (3a, d, e) with triethylorthoformate or with formic acid produced the dihydrothienopyrimidinones (7a-c). The synthesized heterocyclic compounds were screened for antibacterial activities using narrow spectrum against gram-positive and gram-negative bacteriaimage5.gif

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