Efficient Three-Component Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-ones in Green Media

Hamzeh Kiyani

Versions

2021-11-23 (2)
2014-12-11 (1)

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Keywords

Isoxazol-5(4H)-one; Catalyst; Green chemistry; Three-component synthesis.

How to Cite

Kiyani, H. (2021). Efficient Three-Component Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-ones in Green Media. Jordan Journal of Chemistry (JJC), 9(4), 279-288. Retrieved from https://jjc.yu.edu.jo/index.php/jjc/article/view/142 (Original work published December 11, 2014)

Abstract

Several derivatives of 3,4-disubstituted isoxazol-5(4H)-ones were synthesized via a onepot, three-component cyclocondensation reaction of hydroxylamine hydrochloride, various aryl
aldehydes and β-oxoesters. The process takes place in water at room temperature.
Tetrabutylammonium perchlorate (TBAP), sodium oxalate or glycine act as catalysts in
promoting this reaction. The merits of this method are its efficiency, simplicity, cleanness,
greenness, easy work-up, high chemical yields, recyclability, avoidance of using organic
solvents, as well as the relatively short reaction times.

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