The present work includes the synthesis of a series of new 1-(2,4-dinitrophenyl)-3-aryl-7-(substituted benzylidene)-2,3,4,5,6,7-hexahydro-1H-indazoles from substituted chalcones. These chalcones were prepared by the Claisen-Schmidt reaction of condensation of cyclohexanone with various substituted aromatic aldehydes. The synthesized compounds were confirmed by IR, 1H NMR and MASS spectral analysis. The synthesized compounds were screened for anti-inflammatory activity by the gelatin zymography method. The synthesized compounds having unsubstituted phenyl ring at 3rd and 7th positions exhibited maximum activity.