One-Pot Synthesis of 2-Alkyl/arylamino-6-chlorothieno[3,2-e]-1,3-thiazin-4-one

Abstract

2-Alkyl/arylamino-6-chlorothieno[3,2-e]-1,3-thiazin-3-one derivatives were prepared in
one-pot synthesis by refluxing alky/arylisothiocyanates and 2,5-dichloro-3-thiophenecarboxamide. Alternatively, these derivatives were prepared by the intramolecular cyclization of
the deprotonated 2,5-dichloro-N-(alkyl/arylaminocarbonothioyl)thiophene-3-carboxamides, which
were obtained by the reaction of the deprotonated 2,5-dichloro-3-thiophene-carboxamide with
alky/arylisothiocyanates. The structures of the newly synthesized bicyclic derivatives, and their
acyclic precursors, were confirmed based on microanalytical and spectral (IR, MS, and NMR)
data.