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Volume 6, No. 4, December 2011, Muharram 1433 H 




Synthesis of Benzo[6,7][1,2,4]triazepino[4,3a]quinoxaline-6,13(5H,8H)diones from Anthranilic Acid and 1,2-Diaminobenzene

1,2-Diaminobenzene adds to hydrazonoyl chlorides derived from anthranilic acid to yield 2-(2-(3-oxo-3,4-dihydroquinoxalin-2(1H)ylidene)hydrazinyl)benzoic acids 8. The latter compounds cyclize to the corresponding benzo[6,7][1,2,4]triazepino[4,3a]quinoxaline-6,13(5H,8H)diones upon treatment with carbonyldiimidazole 9.



Eyad A. Younes and Ahmad Q. Hussein*

JJC, 2011, 6(4), 361-369

A Zeolite Promoted Synthesis and Antibacterial Activity of Novel Thiazolidinone Derivatives of some Sulphonamide Schiff’s Bases

In the present paper, we have executed the synthesis of substituted 4-(2-(2-chloroquinoline-3-yl)-4-oxothiazolidin-3-yl)-N-phenyl benzene sulphonamide via the reactions of substituted 4-((2-chloroquinoline-3-yl) methylene amino)-N- phenyl benzene sulphonamide with thioglycolic acid and zeolite 78-88% yields at 110 oC under microwave irradiation. This method provides several advantages such as operational simplicity, higher yield, safety and environment friendly protocol. The resulting substituted sulphonamide derivatives were characterized on the basis of 1H NMR, 13C NMR, I.R, elemental analysis, and mass spectral data.



Vandana Tiwari, J.S Meshram*

JJC, 2011, 6(4), 371-383

Synthesis and Structural Characterization of [2,3-Naphtho-12-nitro-5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato]nickel(II)

The title compound was obtained by complexation of the corresponding nitro-chlorin with Ni(OAc)2´4H2O. During this process at 100°C the spontaneous oxidation of chlorin to porphyrin was observed. The product, Ni(II)C52H11F20N5O2×H2O×CH2Cl2, crystallizes in the triclinic system, space group P, with cell constants a = 7.5855(2) Å, b = 15.5580(4) Å, c = 21.1029(5) Å, α = 91.675(2)°, β = 96.294(2)°, γ = 96.212(2)°, V = 2458.79(11) Å3, and Z = 2. The nickel(II) atom is coordinated by four N-atoms from porphyrin core and the NiN4 unit adopts a square-planar geometry. The Ni–N bond lengths are within the range 1.887(4)–1.931(4) Å, while the average N–Ni–N angles are 178.83 and 90.01°. The porphyrin core 20-membered ring adopts non-planar saddle conformation and the four pentafluorophenyl substituents are oriented nearly perpendicular to the macrocyclic porphyrin system. The molecular packing in the crystal is influenced by π×××π interactions of the naphthalene rings and weak intermolecular C–H×××F dipole–dipole attractions linking the Ni(II)-porphyrin complex and dichloromethane molecules.


Zbigniew Karczmarzyk*, Przemysław Wyrębek, Waldemar Wysocki, Stanisław Ostrowski, Zofia Urbańczyk-Lipkowska and Przemysław Kalicki

JJC, 2011, 6(4), 385-392

A Selective Optical Chemosensor for Iron(III) Ions in Aqueous Medium Based on [bis(2,2`-bipyridine)-bis(2-carboxypyridine)]ruthenium(II) Complex

The ruthenium(II) complex (cis-[bis(2,2`-bipyridine)-bis(2-carboxypyridine)]ruthenium(II) bis(hexafluorophosphate) has been synthesized and characterized using standard analytical and spectroscopic techniques, FTIR, 1H and 13C-NMR, UV/vis, elemental analysis, conductivity measurements and potentiometric titration. Investigation of the synthesized complex with metal ions showed that this complex has absorption properties that are selective and sensitive toward the presence of iron(III) ion in an aqueous solution. The detection limit for Fe(III) ion using UV/vis spectroscopy is estimated to be ~ 0.1 ppm. The results presented In the article have important implication in the development of an optical selective detection for iron(III) ions in aqueous solution.


Amer Al Abdel Hamid*, Carl P. Tripp, Alice E. Bruce and Mitchell R. M. Bruce

JJC, 2011, 6(4), 393-401

Spectrophotometric Determination of Oxymetazoline Hydrochloride Based on the Oxidation Reactions

Simple, sensitive and reproducible spectrophotometric method was developed for determination of oxymetazoline hydrochloride in pure as well as in pharmaceutical drop formulations. The method is based on the reduction of ferric to ferrous ions followed by complexation with 1,10-phenanthroline to produce an orange red chromogen that has maximum absorption at 510 nm and obeyed Beer’s linearity in the concentration range of 0.1-7 mg/ml, with molar absorptivity 5.74×104 l.mol-1cm-1, accuracy (average recovery %) 100.53 % and precision better than 1.6. The developed method was successfully applied to the determination of oxymetazoline hydrochloride in bulk and pharmaceutical formulations without any interference from common excipients.


Theia'a N. Al-Sabha* and Bassam A. Rasheed

JJC, 2011, 6(4), 403-411

Spectrophotometric Methods for the Determination of Nimodipine in Pure and in Pharmaceutical Preparations

The developed methods are based on the diazo-coupling reaction of reduced nimodipine with nitrous acid followed by coupling with acetylacetone (Method A), diphenylamine (Method B), citrazinic acid (Method C) and chromotropic acid (Method D) as coupling agents. The absorbance of the colored azo-dyes shows λmax at 420, 540, 440 and 520 nm.



Hosakere D. Revanasiddappa*, Shiramahally M. Mallegowda, Hemavathi N. Deepakumari and Kanakapura B. Vinay

JJC, 2011, 6(4), 413-422

Novel PVC Membrane Selective Electrode for the Determination of Etoricoxib in Pharmaceutical Preparations

The construction and general performance characteristics of novel potentiometric membrane sensors responsive to the etoricoxib are described. The sensors are based on the use of ion-pair complex of etoricoxib (ET) with Picric Acid Pc-H (ET- Pc-H) as exchange sites in a with different plasticizers dibutyl phthalate (DBP) (electrode B) tri-n-butyl phosphate (TBP) (electrode C), or dioctylphthalate (DOP) (electrode A). The electrodes show a fast, stable and near- Nernstian for the mono charge cation of ET over the concentration range 0.09 - 42.96 mM at 25 ˚C over the pH range 5-14 with cationic slope of 56.8 ± 0.5 and 55.0 ± 0.5 per concentration decade for ET-B and ET-A electrodes respectively. The lower detection limit is 0.05 mM and 0.07 mM with the response time 15s in the same order of both electrodes. Selectivity coefficients of ET related to a number of interfering cations and some organic compounds were investigated. There are negligible interference caused by most of the investigated species. The direct determination of 0.5 - 20 mM of ET shows an average recovery of 99.62 - 102.40% and 100.27-102.61 a mean relative standard deviation 2.75-0.64 and 1.76-0.41 for A and B electrodes respectively. The results obtained by determination of ET in tablets using the proposed electrodes which comparable favorably with those obtained by spectrophotometric method. Validation of the method shows the suitability of the electrodes for the determination of ET in pharmaceutical formulations.


Salwa Rassi*, Basher Elias, Mohammed Samer Bassmajei

 JJC, 2011, 6(4), 423-437

An, In Vitro, Study of some Pesticides on the Activity of Human Serum Paraoxonase (PON1)

Paraoxonase-1 (PON1) is a high density lipoprotein (HDL)-associated enzyme capable of hydrolyzing diverse substrates from organophosphate (OP) toxins to oxidized phospholipids. In this study, the effects of dichlorvos, parathion-methyl, dimethoate, chlorpyrifos methyl, chlorpyrifos ethyl, acetamiprid, mancozeb, lufenuron and trifluralin which are pesticides, were investigated on human serum paraoxonase as in vitro. While trifluralin, mancozeb and methyl parathion enhanced the PON activity, lufenuron, dimetoate and chlorpyrifos methyl and chlorpyrifos ethyl firstly activated and then they inhibited in the different range of enzyme activity.  It was determined that acetamidine and dichlorvos were inhibited and the CI50 values of the chemicals caused inhibition were calculated by means of activity percentage-[I] diagrams. The values of CI50 were 38,19 mM and 13,49 mM for PON1 respectively. Changes of PON enzyme’s kinetic parameters were most important during pesticide metabolism, because pesticides were risk for human health.



Nazan Demir*, Hayrunnisa Nadaroğlu, Yaşar Demir, Azize Alayli Güngör

JJC, 2011, 6(4), 439-451

Alterations in Lipid Peroxidation and some Trace Elements Concentrations in Sera and Tissues Homogenates of Women with Benign and Malignant Cervix and Uterine Tumors

In this study, levels of MDA, as an end product of lipid peroxidation, were measured in sera and tissue homogenates of patients with benign and malignant cervix and uterine tumors in comparison with that of control women. Also some trace elements (Cu, Fe, and Zn) were measured to investigate the relationship between these trace elements and lipid peroxidation in the above indicated patients.



Hathama Razooki Hasan* and Shatha Abd AL-Wadood Al-Shammaree

JJC, 2011, 6(4), 453-465