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Volume 5, No. 2, June 2010, Rajab 1431 H

Articles

 

 

Microwave-Assisted Synthesis and Antioxidant Properties of Some New 1,2,4-Triazole Derivatives

A series of new 5-(substituted biphenyl-4-yl)-3-(methoxyphenyl)-1-methyl-1H-1,2,4-triazoles (5-15) were successfully synthesized by Suzuki coupling between 5-(4-bromophenyl)-3-(substituted methoxyphenyl)-1-methyl-1H-1,2,4-triazoles (3 and 4), which were used as key intermediates for the synthesis of our targets, and the appropriate boronic acid.

 

 

Yaseen A. Al-Soud*, Hamdoon A. Mohammed and Anwar Abo-Amer

 JJC, 2010, 5(2), 119-129

Synthesis of 3-Deoxyclarithromycin through Biotransformation of Clarithromycin by Aspergillus niger and its Antibacterial Activity

Biotransformation of clarithromycin (1), by the plant pathogen Aspergillus niger ATCC 10549, produced one main metabolite identified as 3-deoxyclarithromycin (2). Testing the antibacterial activity against Staphylococcus aureus and Escherichia coli showed that compound 2 has a moderate activity against the tested bacteria.

 

 

Amal Al-Aboudi*

JJC, 2010, 5(2), 131-138

Solid Phase Synthesis and Antiparasitic Activity of a Library of Peptidyl Metronidazoles

A number of peptidyl metronidazole derivatives were synthesized in 99% yield through solid phase peptide synthesis. The newly prepared compounds were tested against Entamoeba histolytica and Giardia intestinalis and were found to be much less active than metronidazole against the aforementioned parasites.

 

Samer Al-Gharabli*, Nafisah Al-Rifai, Haythem A. Saadeh, Ibrahim M. Mosleh and  Mohammad S. Mubarak*

JJC, 2010, 5(2), 139-147

 

Non-Covalent Interactions Involved in the Crystal Structure of Proton-Transfer Compounds of Saccharinate Anion and Different Cations

The synthesis and self-assembly of the proton-transfer compounds 4 and 5 of saccharin and nitrogen-containing aromatic derivatives were reported and discussed in terms of crystal engineering and supramolecular chemistry. Both compounds contain cationic and anionic fragments interacting through hydrogen bonding patterns to produce ionic supramolecular heterosynthon.

 

 

Nawash Al-ghezawi*

JJC, 2010, 5(2), 149-155

Synthesis and Crystal Structure of Bis-[Co(L)(NCS)(MeOH)], where (LH = 4-(Salicylaldimine) antipyrine)

The title complex was isolated as red solid material from the reaction of Co(SCN)2 with 4-(Salicylaldimine) antipyrine in ethanol. The molecular structure has been determined by elemental analysis, FTIR, UV-Vis and X-ray diffraction. The crystallographic data are: monoclinic P21/n, a = 9.8335(3) , b = 18.8593(6) , c = 11.2921(4) , a = 90, b = 102.880(2), g = 90, V = 2041.46(12) 3 and Z = 2, R =0.045.  The dicobalt (II) complex is centrosymmetric dimer in which the Co(II) ions are six coordinate being bonded to three coordinating donor sites from the corresponding tridentate Schiff base ligand and the fourth one is relatively bonded by phenolic oxygen, the fifth and sixth donor sites comes from isothiocyanate and methanol.

 

 

El-Mehdawi R. M., Eldewik* A. N., Kreddan K. M., El-Hamruni S. H., Hend ben Hussien, Hitchcok P. B. and Shabash A. A.

JJC, 2010, 5(2), 157-164

The Effect of Bath Temperature on the Chemical Bath Deposition of Copper Sulphide Thin Films

Copper sulphide thin films were deposited onto indium tin oxide glass substrates at various bath temperatures by chemical bath deposition technique. XRD studies demonstrated that the thin films had hexagonal structure and confirmed the improvement of crystallinity of the films by increasing the bath temperature. Meanwhile, the surface roughness, film thickness and grain size were also increased with increasing of bath temperature from 25 to 45 C.  However, the films deposited at 25 C were uniform, smaller grain size and covered the substrate surface completely according to AFM images.Optical absorption analysis indicated that the band gap values were increased from 2.5 to 2.7 eV as the bath temperature was decreased from 45 to 25 C.

 

 

Anuar Kassim*, Tan Wee Tee, Saravanan Nagalingam and Ho Soon Min

JJC, 2010, 5(2), 165-173

The Inhibiting Effects of Alkyl Benzene Sulphonate and the Magnetic Field on Aluminum Corrosion in Acidic Solution

 

Corrosion inhibition of aluminum (Al) in hydrochloric acid (HCl) by linear alkyl benzene sulphonate (LABS) in the presences and absences of external magnetic field has been studied using weight-loss and hydrogen evolution methods. The inhibition action depends on the chemical structure and the concentration of the inhibitor, the concentration of the corrosive medium, the temperature, and the presence of an external magnetic field (0.1 T was applied). The percentage inhibition efficiency (%IE) of aluminum corrosion with LABS is slightly increased in the presences of an external magnetic field.  The %IE decreases as the concentration of HCl increases. For the tested additives, an increase in the temperature was found to decrease the %IE.

 

 

A. K. Maayta,
N. A. F. Al-Rawashdeh*

JJC, 2010, 5(2), 175-189

Concentrations of some Heavy Metals (Cd, Cu, Pb Se and Sn) in Human Teeth at Different Ages and the Correlation to Caries

 

The present study aims to measure the concentrations of some heavy metals like cadmium (Cd), copper (Cu), lead (Pb), selenium (Se), and tin (Sn) in human teeth using graphite furnace atomic absorption spectrometry (GFAAS). Forty one Teeth specimens were collected from people living in the Capital of Jordan Amman. Teeth specimens of different classes were analyzed like incisors, molars, and premolars. There are relationships between the concentrations of Cd, Cu, Pb, Se and Sn and gender, age and smoking with caries degree. In addition, the concentrations of the studied metals in teeth of males were higher in smokers than those from nonsmokers, but the concentrations of these heavy metals were approximately the same for smoker and nonsmoker females. Also, Caries doesnt affect the concentrations of Cu, Pb and Se in human teeth, but it increases the concentrations of Cd and Sn. Furthermore, no brushing the teeth daily but randomly through the week and rareness of the frequent visits to the dentist clinic are the main reasons for inducing caries. The concentrations of Cd, Cu, Pb, Se and Sn are found to increase with age due to accumulation.

 

 

Mahmoud A. Alawi*, Aseel Abusbaih

JJC, 2010, 5(2), 191-199

Spectrophotometric Method for Determination of Chloramphenicol in Pharmaceutical Preparations using 1,2-Naphthoquinone-4-Sulphonate as a Chromogenic Reagent

 

A simple, sensitive and rapid spectrophotometric method for the determination of chloramphenicol in pure as well as in dosage form is described. The method is based on the condensation reaction of reduced chloramphenicol with sodium 1,2-naphthaquinone-4-sulfonate (NQS) in an alkaline medium to form an orange-red colored Schiff's base of maximum absorption peak (λmax) at 480 nm. Under the optimized reaction conditions, Beers law correlating the absorbance with chloramphenicol concentration was obeyed in the range of 0.8-14 μg ml-1. The molar absorptivity was 1.02104 L mol1cm1. The limits of detection and quantitation were 0.124 and 0.473 μg ml-1, respectively. The accuracy and precision of the method were satisfactory; the average recovery was 99.54 % and values of relative standard deviations better than 3.5 %. The stoichiometry of the reaction was studied, and the reaction mechanism was postulated. The proposed method was successfully applied to the determination of chloramphenicol in its pharmaceutical capsule, syrup and ointment with good accuracy and precisions. The results obtained by the proposed method are compared with those obtained by the official method.

 

 

 

Theia'a N. Al-Sabha* and Bassam A. Rasheed

JJC, 2010, 5(2), 201-210